Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Neuroscience and Biobehavioral Reviews Année : 2020

Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review

Résumé

Autoimmune Limbic Encephalitis (LE) is a relatively new category of immune-mediated diseases with a wide range of neuropsychiatric symptoms. LE associated with Glutamic Acid Decarboxylase (GAD) antibodies is difficult to diagnose due to its possible atypical presentation with neuropsychiatric and behavioral features. We performed a systematic review of literature and retrieved 21 cases of anti GAD-associated LE with neuropsychiatric signs. Median age at onset was 27 years with a female predominance (81.0 %) and median diagnostic delay of 6 months. Clinical presentation included typical LE symptoms such as anterograde amnesia (95.2 %) and temporal lobe or tonico-clonic seizures (95.2 %). Psychiatric symptoms were described in 61.9 % of patients, presenting as anxiety, depressive symptoms, apathy and behavioral changes. Extra-limbic symptoms were present in 14.3 % of patients. No neoplasia associated was found. Some patients had poor epileptic, cognitive and psychiatric outcomes requiring prolonged immunosuppressive treatment. The description of the neuropsychiatric spectrum of anti-GAD LE and its specificities aims to improve our understanding of this entity, and may lead to earlier diagnosis as well as better outcome.
Fichier principal
Vignette du fichier
S0149763420305534.pdf (581.4 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03493433 , version 1 (17-10-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Agathe Vrillon, Guilhem Carle, Giulia Berzero, Jérôme Honnorat, Gilles Huberfeld, et al.. Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review. Neuroscience and Biobehavioral Reviews, 2020, 119, pp.128 - 137. ⟨10.1016/j.neubiorev.2020.08.015⟩. ⟨hal-03493433⟩
486 Consultations
71 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More