New method for quantification of intratumoral heterogeneity: a feasibility study on Ktrans maps from preclinical DCE-MRI - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Magnetic Resonance Materials in Physics, Biology and Medicine Année : 2021

New method for quantification of intratumoral heterogeneity: a feasibility study on Ktrans maps from preclinical DCE-MRI

Résumé

Object: To develop new imaging biomarkers of therapeutic efficacy through the quantification of intratumoral microvascular heterogeneity. Materials and Methods: The described method was a combination of non-supervised clustering and extraction of intratumoral complexity features (ICF): number of non-connected objects, volume fraction. It was applied to a set of 3D DCE-MRI K trans maps acquired previously on tumor bearing mice prior to and on day 4 of anti-angiogenic treatment. Evolutions of ICF were compared to conventional summary statistics (CSS) and to heterogeneity related whole tumor texture features (TF) on treated (n=9) and control (n=6) mice. Results: Computed optimal number of clusters per tumor was 4. Several intratumoral features extracted from the clusters were able to monitor a therapy effect. Whereas no feature significantly changed for the control group, 6 features significantly changed for the treated group (4 ICF, 2 CSS). Among these, 5 also significantly differentiated the two groups. (3 ICF, 2 CSS). TF failed in demonstrating differences within and between the two groups. Discussion: ICF are potential imaging biomarkers for anti-angiogenic therapy assessment. The presented method is expected to have advantages with respect to texture analysis based methods regarding interpretability of results and setup of standardized image analysis protocols.
Fichier principal
Vignette du fichier
HAL Girot 2021.pdf (975.44 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03328004 , version 1 (27-08-2021)

Identifiants

Citer

Charly Girot, Andreas Volk, Christine Walczak, Nathalie Lassau, Stéphanie Pitre. New method for quantification of intratumoral heterogeneity: a feasibility study on Ktrans maps from preclinical DCE-MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 2021, 34, ⟨10.1007/s10334-021-00930-3⟩. ⟨hal-03328004⟩
96 Consultations
83 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More