ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles (Review Article) Cancers Year : 2021

ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment

Abstract

The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells, fibroblasts, adipocytes and endothelial cells, the extracellular matrix (ECM) and the cytokine/growth factors. Within this space, proteins of the adamalysin family (ADAM for a disintegrin and metalloproteinase; ADAMTS for ADAM with thrombospondin motifs; ADAMTSL for ADAMTS-like) play critical roles by modulating cell–cell and cell–ECM communication. During last decade, the implication of adamalysins in the development of hepatocellular carcinoma (HCC) has been supported by numerous studies however the functional characterization of most of them remain unsettled. In the present review we propose both an overview of the literature and a meta-analysis of adamalysins expression in HCC using data generated by The Cancer Genome Atlas (TCGA) Research Network
Fichier principal
Vignette du fichier
cancers-13-01563-v3.pdf (2.98 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03215892 , version 1 (03-05-2021)

Licence

Identifiers

Cite

Nathalie Theret, Fidaa Bouezzeddine, Fida Azar, Mona Diab-Assaf, Vincent Legagneux. ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment. Cancers, 2021, 13 (7), pp.1563. ⟨10.3390/cancers13071563⟩. ⟨hal-03215892⟩
90 View
188 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More