%0 Journal Article %T Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome %+ Department of Experimental Cardiology, Amsterdam University Medical Center %+ Department of Medical Biology, Amsterdam University Medical Center %+ IHU-LIRYC %+ Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN) %+ Institut de Mathématiques de Bordeaux (IMB) %A Boukens, Bastiaan %A Potse, Mark %A Coronel, Ruben %Z RHYTHM (Leducq 16CVD02): This work was supported by the French National Research Agency, grant reference ANR-10-IAHU04-LIRYC. Dutch Heart Foundation (2016T047). Simulations were performed on HPC resources of IDRIS under GENCI allocation x2015037379. %< avec comité de lecture %@ 1661-6596 %J International Journal of Molecular Sciences %I MDPI %V 22 %N 4 %P 1570 %8 2021-02-04 %D 2021 %R 10.3390/ijms22041570 %K Arrhythmias %K Brugada syndrome %K Early repolarization pattern %K Fibrosis %K Conduction %K Repolarization %Z Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemJournal articles %X Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. The Brugada syndrome is now considered a conduction disorder based on subtle structural abnormalities in the right ventricular outflow tract. Recent evidence suggests structural substrate in patients with the early repolarization syndrome as well. We propose a unifying mechanism based on these structural abnormalities explaining both arrhythmogenesis and the electrocardiographic changes. In addition, we speculate that, with increasing technical advances in imaging techniques and their spatial resolution, these syndromes will be reclassified as structural heart diseases or cardiomyopathies. %G English %2 https://inria.hal.science/hal-03133273/document %2 https://inria.hal.science/hal-03133273/file/boukens-overlap.pdf %L hal-03133273 %U https://inria.hal.science/hal-03133273 %~ CNRS %~ INRIA %~ INRIA-BORDEAUX %~ CARDIO %~ INRIA_TEST %~ TESTALAIN1 %~ TESTBORDEAUX %~ INRIA2 %~ GENCI %~ ANR %~ INRIAARTDOI