<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03046771</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T00:18:41+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis</title>
            <author role="aut">
              <persName>
                <forename type="first">Virgilio</forename>
                <surname>Kmetzsch</surname>
              </persName>
              <email type="md5">3e73bca0590170947f8a34b68b2ea463</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">virgilio-kmetzsch</idno>
              <idno type="idhal" notation="numeric">741319</idno>
              <idno type="halauthorid" notation="string">52188-741319</idno>
              <affiliation ref="#struct-542032"/>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Anquetil</surname>
              </persName>
              <idno type="idhal" notation="numeric">761637</idno>
              <idno type="halauthorid" notation="string">411667-761637</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6912-9908</idno>
              <idno type="IDREF">https://www.idref.fr/137975783</idno>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dario</forename>
                <surname>Saracino</surname>
              </persName>
              <email type="md5">d35f45dc33c42447c65a79661eb12a23</email>
              <email type="domain">etu.upmc.fr</email>
              <idno type="idhal" notation="string">dario-saracino</idno>
              <idno type="idhal" notation="numeric">748160</idno>
              <idno type="halauthorid" notation="string">45899-748160</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4299-9743</idno>
              <idno type="IDREF">https://www.idref.fr/264734793</idno>
              <affiliation ref="#struct-542032"/>
              <affiliation ref="#struct-542029"/>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-353778"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daisy</forename>
                <surname>Rinaldi</surname>
              </persName>
              <idno type="halauthorid">632318-0</idno>
              <affiliation ref="#struct-542029"/>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-353778"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Agnès</forename>
                <surname>Camuzat</surname>
              </persName>
              <idno type="halauthorid">282796-0</idno>
              <affiliation ref="#struct-542029"/>
              <affiliation ref="#struct-110691"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Gareau</surname>
              </persName>
              <idno type="halauthorid">2099340-0</idno>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ludmila</forename>
                <surname>Jornea</surname>
              </persName>
              <idno type="halauthorid">976664-0</idno>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Forlani</surname>
              </persName>
              <idno type="halauthorid">242064-0</idno>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Couratier</surname>
              </persName>
              <email type="md5">9aca7c28ae9e3d61104ef3af0fa00907</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="string">couratierphilippe</idno>
              <idno type="idhal" notation="numeric">1042707</idno>
              <idno type="halauthorid" notation="string">526472-1042707</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9562-856X</idno>
              <idno type="VIAF">https://viaf.org/viaf/172769838</idno>
              <affiliation ref="#struct-58106"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Wallon</surname>
              </persName>
              <email type="md5">8dc2d34386190277fae2f01b0b328081</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">davidwallon</idno>
              <idno type="idhal" notation="numeric">178526</idno>
              <idno type="halauthorid" notation="string">21207-178526</idno>
              <idno type="IDREF">https://www.idref.fr/157825809</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2634-7198</idno>
              <affiliation ref="#struct-300318"/>
              <affiliation ref="#struct-300147"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Pasquier</surname>
              </persName>
              <email type="md5">c6c6b8fcc4f256474f9bc26a0dc5d7bd</email>
              <email type="domain">chru-lille.fr</email>
              <idno type="idhal" notation="numeric">921850</idno>
              <idno type="halauthorid" notation="string">168854-921850</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9880-9788</idno>
              <idno type="IDREF">https://www.idref.fr/03434991X</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1432-5300</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-1527-2017</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-1527-2017</idno>
              <affiliation ref="#struct-374570"/>
              <affiliation ref="#struct-42992"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Noémie</forename>
                <surname>Robil</surname>
              </persName>
              <idno type="halauthorid">2099341-0</idno>
              <affiliation ref="#struct-1003143"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>de La Grange</surname>
              </persName>
              <idno type="halauthorid">584856-0</idno>
              <affiliation ref="#struct-1003143"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ivan</forename>
                <surname>Moszer</surname>
              </persName>
              <idno type="halauthorid">739409-0</idno>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Le Ber</surname>
              </persName>
              <idno type="halauthorid">222137-0</idno>
              <affiliation ref="#struct-542029"/>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-542030"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Colliot</surname>
              </persName>
              <email type="md5">c8577f1fc4d652291f326ab4e96a62e2</email>
              <email type="domain">upmc.fr</email>
              <idno type="idhal" notation="string">olivier-colliot</idno>
              <idno type="idhal" notation="numeric">5286</idno>
              <idno type="halauthorid" notation="string">53376-5286</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/B-2092-2012</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9836-654X</idno>
              <idno type="IDREF">https://www.idref.fr/085263893</idno>
              <idno type="ARXIV">https://arxiv.org/a/colliot_o_1</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/B-2092-2012</idno>
              <affiliation ref="#struct-542032"/>
              <affiliation ref="#struct-542029"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuelle</forename>
                <surname>Becker</surname>
              </persName>
              <email type="md5">17f906906dc02cfef1d792176e8a14f3</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">emmanuelle-becker</idno>
              <idno type="idhal" notation="numeric">1084966</idno>
              <idno type="halauthorid" notation="string">522614-1084966</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7673-0582</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-2523-2015</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-2523-2015</idno>
              <affiliation ref="#struct-491479"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Virgilio</forename>
                <surname>Kmetzsch</surname>
              </persName>
              <email type="md5">3e73bca0590170947f8a34b68b2ea463</email>
              <email type="domain">inria.fr</email>
            </editor>
            <funder ref="#projanr-50388"/>
            <funder ref="#projanr-26971"/>
            <funder ref="#projanr-41011"/>
            <funder ref="#projanr-38027"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-12-08 15:30:45</date>
              <date type="whenModified">2026-01-23 09:12:07</date>
              <date type="whenReleased">2020-12-08 16:07:46</date>
              <date type="whenProduced">2020-11-25</date>
              <date type="whenEndEmbargoed">2020-12-08</date>
              <ref type="file" target="https://inria.hal.science/hal-03046771v1/document">
                <date notBefore="2020-12-08"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://inria.hal.science/hal-03046771v1/file/jnnp-2020-324647.full.pdf" id="file-3046771-2681895">
                <date notBefore="2020-12-08"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053348"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="956450">
                <persName>
                  <forename>Virgilio</forename>
                  <surname>Kmetzsch</surname>
                </persName>
                <email type="md5">3e73bca0590170947f8a34b68b2ea463</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03046771</idno>
            <idno type="halUri">https://inria.hal.science/hal-03046771</idno>
            <idno type="halBibtex">kmetzsch:hal-03046771</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Neurology, Neurosurgery and Psychiatry&lt;/i&gt;, 2020, 92 (5), pp.485-493. &lt;a target="_blank" href="https://dx.doi.org/10.1136/jnnp-2020-324647"&gt;&amp;#x27E8;10.1136/jnnp-2020-324647&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Neurology, Neurosurgery and Psychiatry, 2020, 92 (5), pp.485-493. &amp;#x27E8;10.1136/jnnp-2020-324647&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3046771-2681895"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="UNIV-UBS">Université de Bretagne Sud</idno>
            <idno type="stamp" n="INSA-RENNES">Institut National des Sciences Appliquées de Rennes</idno>
            <idno type="stamp" n="INRIA-RENNES">INRIA Rennes - Bretagne Atlantique</idno>
            <idno type="stamp" n="INRIA-ROCQ">INRIA Paris - Rocquencourt</idno>
            <idno type="stamp" n="IRISA">Irisa</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="IRISA_SET">IRISA_SET</idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="TESTALAIN1">TESTALAIN1</idno>
            <idno type="stamp" n="ICM" corresp="SORBONNE-UNIVERSITE">Institut du Cerveau et de la Moëlle Epinière</idno>
            <idno type="stamp" n="CENTRALESUPELEC">Ecole CentraleSupélec</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="INRIA2">INRIA 2</idno>
            <idno type="stamp" n="ARAMISLAB">ARAMISLAB - Algorithms, models and methods for images and signals of the human brain </idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UR1-MATH-STIC">UR1 - publications Maths-STIC</idno>
            <idno type="stamp" n="UR1-UFR-ISTIC">UFR ISTIC Informatique et électronique</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="INRIA-RENGRE">INRIA-RENGRE</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="PNRIA">Programme National de Recherche en IA</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="PRAIRIE-IA">PaRis AI Research InstitutE</idno>
            <idno type="stamp" n="UR1-MATH-NUM">Pôle UnivRennes - Mathématiques - Numérique </idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="INRIAARTDOI">INRIAARTDOI</idno>
            <idno type="stamp" n="SUPRA_MEDECINE_AUTRE">Médecine (hors SVE6)</idno>
            <idno type="stamp" n="ANR-IA-19" corresp="ANR-IA">ANR-IA-19</idno>
            <idno type="stamp" n="ANR-IA">ANR-IA</idno>
            <idno type="stamp" n="ANR_SANTE_MENTALE">ANR SANTE MENTALE</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Virgilio</forename>
                    <surname>Kmetzsch</surname>
                  </persName>
                  <email type="md5">3e73bca0590170947f8a34b68b2ea463</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">virgilio-kmetzsch</idno>
                  <idno type="idhal" notation="numeric">741319</idno>
                  <idno type="halauthorid" notation="string">52188-741319</idno>
                  <affiliation ref="#struct-542032"/>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Anquetil</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">761637</idno>
                  <idno type="halauthorid" notation="string">411667-761637</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6912-9908</idno>
                  <idno type="IDREF">https://www.idref.fr/137975783</idno>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dario</forename>
                    <surname>Saracino</surname>
                  </persName>
                  <email type="md5">d35f45dc33c42447c65a79661eb12a23</email>
                  <email type="domain">etu.upmc.fr</email>
                  <idno type="idhal" notation="string">dario-saracino</idno>
                  <idno type="idhal" notation="numeric">748160</idno>
                  <idno type="halauthorid" notation="string">45899-748160</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4299-9743</idno>
                  <idno type="IDREF">https://www.idref.fr/264734793</idno>
                  <affiliation ref="#struct-542032"/>
                  <affiliation ref="#struct-542029"/>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-353778"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daisy</forename>
                    <surname>Rinaldi</surname>
                  </persName>
                  <idno type="halauthorid">632318-0</idno>
                  <affiliation ref="#struct-542029"/>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-353778"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Agnès</forename>
                    <surname>Camuzat</surname>
                  </persName>
                  <idno type="halauthorid">282796-0</idno>
                  <affiliation ref="#struct-542029"/>
                  <affiliation ref="#struct-110691"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Gareau</surname>
                  </persName>
                  <idno type="halauthorid">2099340-0</idno>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ludmila</forename>
                    <surname>Jornea</surname>
                  </persName>
                  <idno type="halauthorid">976664-0</idno>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Forlani</surname>
                  </persName>
                  <idno type="halauthorid">242064-0</idno>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Couratier</surname>
                  </persName>
                  <email type="md5">9aca7c28ae9e3d61104ef3af0fa00907</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="string">couratierphilippe</idno>
                  <idno type="idhal" notation="numeric">1042707</idno>
                  <idno type="halauthorid" notation="string">526472-1042707</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9562-856X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/172769838</idno>
                  <affiliation ref="#struct-58106"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Wallon</surname>
                  </persName>
                  <email type="md5">8dc2d34386190277fae2f01b0b328081</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">davidwallon</idno>
                  <idno type="idhal" notation="numeric">178526</idno>
                  <idno type="halauthorid" notation="string">21207-178526</idno>
                  <idno type="IDREF">https://www.idref.fr/157825809</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2634-7198</idno>
                  <affiliation ref="#struct-300318"/>
                  <affiliation ref="#struct-300147"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Pasquier</surname>
                  </persName>
                  <email type="md5">c6c6b8fcc4f256474f9bc26a0dc5d7bd</email>
                  <email type="domain">chru-lille.fr</email>
                  <idno type="idhal" notation="numeric">921850</idno>
                  <idno type="halauthorid" notation="string">168854-921850</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9880-9788</idno>
                  <idno type="IDREF">https://www.idref.fr/03434991X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1432-5300</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-1527-2017</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-1527-2017</idno>
                  <affiliation ref="#struct-374570"/>
                  <affiliation ref="#struct-42992"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Noémie</forename>
                    <surname>Robil</surname>
                  </persName>
                  <idno type="halauthorid">2099341-0</idno>
                  <affiliation ref="#struct-1003143"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>de La Grange</surname>
                  </persName>
                  <idno type="halauthorid">584856-0</idno>
                  <affiliation ref="#struct-1003143"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ivan</forename>
                    <surname>Moszer</surname>
                  </persName>
                  <idno type="halauthorid">739409-0</idno>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Le Ber</surname>
                  </persName>
                  <idno type="halauthorid">222137-0</idno>
                  <affiliation ref="#struct-542029"/>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-542030"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Colliot</surname>
                  </persName>
                  <email type="md5">c8577f1fc4d652291f326ab4e96a62e2</email>
                  <email type="domain">upmc.fr</email>
                  <idno type="idhal" notation="string">olivier-colliot</idno>
                  <idno type="idhal" notation="numeric">5286</idno>
                  <idno type="halauthorid" notation="string">53376-5286</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/B-2092-2012</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9836-654X</idno>
                  <idno type="IDREF">https://www.idref.fr/085263893</idno>
                  <idno type="ARXIV">https://arxiv.org/a/colliot_o_1</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/B-2092-2012</idno>
                  <affiliation ref="#struct-542032"/>
                  <affiliation ref="#struct-542029"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuelle</forename>
                    <surname>Becker</surname>
                  </persName>
                  <email type="md5">17f906906dc02cfef1d792176e8a14f3</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">emmanuelle-becker</idno>
                  <idno type="idhal" notation="numeric">1084966</idno>
                  <idno type="halauthorid" notation="string">522614-1084966</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7673-0582</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-2523-2015</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-2523-2015</idno>
                  <affiliation ref="#struct-491479"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15872</idno>
                <idno type="issn">0022-3050</idno>
                <idno type="eissn">1468-330X</idno>
                <title level="j">Journal of Neurology, Neurosurgery and Psychiatry</title>
                <imprint>
                  <publisher>BMJ Publishing Group</publisher>
                  <biblScope unit="volume">92</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">485–493</biblScope>
                  <date type="datePub">2020-11-25</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1136/jnnp-2020-324647</idno>
              <idno type="pubmed">33239440</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
              <classCode scheme="halDomain" n="stat.ml">Statistics [stat]/Machine Learning [stat.ML]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Objective: To identify potential biomarkers of preclinical and clinical progression in chromosome 9 open reading frame 72 gene (C9orf72)-associated disease by assessing the expression levels of plasma microRNAs (miRNAs) in C9orf72 patients and presymptomatic carriers. Methods: The PREV-DEMALS study is a prospective study including 22 C9orf72 patients, 45 presymptomatic C9orf72 mutation carriers and 43 controls. We assessed the expression levels of 2576 miRNAs, among which 589 were above noise level, in plasma samples of all participants using RNA sequencing. The expression levels of the differentially expressed miRNAs between patients, presymptomatic carriers and controls were further used to build logistic regression classifiers. Results: Four miRNAs were differentially expressed between patients and controls: miR-34a-5p and miR-345-5p were overexpressed, while miR-200c-3p and miR-10a-3p were underexpressed in patients. MiR-34a-5p was also overexpressed in presymptomatic carriers compared with healthy controls, suggesting that miR-34a-5p expression is deregulated in cases with C9orf72 mutation. Moreover, miR-345-5p was also overexpressed in patients compared with presymptomatic carriers, which supports the correlation of miR-345-5p expression with the progression of C9orf72-associated disease. Together, miR-200c-3p and miR-10a-3p underexpression might be associated with full-blown disease. Four presymptomatic subjects in transitional/prodromal stage, close to the disease conversion, exhibited a stronger similarity with the expression levels of patients. Conclusions: We identified a signature of four miRNAs differentially expressed in plasma between clinical conditions that have potential to represent progression biomarkers for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis. This study suggests that dysregulation of miRNAs is dynamically altered throughout neurodegenerative diseases progression, and can be detectable even long before clinical onset. Trial registration number NCT02590276. copyright.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-542032" status="VALID">
          <idno type="RNSR">201221057R</idno>
          <idno type="ROR">https://ror.org/02wpx0e31</idno>
          <orgName>Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]</orgName>
          <orgName type="acronym">ARAMIS</orgName>
          <date type="start">2018-01-01</date>
          <date type="end">2026-06-30</date>
          <desc>
            <address>
              <addrLine>Hôpital de la Pitié-Salpêtrière Batiment ICM 47 boulevard de l'hopital 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/equipes/aramis</ref>
          </desc>
          <listRelation>
            <relation active="#struct-542029" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation name="U1127" active="#struct-303623" type="indirect"/>
            <relation active="#struct-353778" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
            <relation name="UM75" active="#struct-413221" type="indirect"/>
            <relation name="UMR7225" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1175218" type="direct"/>
            <relation active="#struct-454310" type="indirect"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-542029" status="VALID">
          <idno type="IdRef">162466021</idno>
          <idno type="ISNI">0000000406205939</idno>
          <idno type="RNSR">200918525B</idno>
          <idno type="ROR">https://ror.org/050gn5214</idno>
          <orgName>Institut du Cerveau = Paris Brain Institute</orgName>
          <orgName type="acronym">ICM</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="U1127" active="#struct-303623" type="direct"/>
            <relation active="#struct-353778" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UM75" active="#struct-413221" type="direct"/>
            <relation name="UMR7225" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-58106" status="VALID">
          <orgName>Service de Neurologie [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren 2 avenue Martin-Luther-King 87042 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300147" status="VALID">
          <idno type="IdRef">169975681</idno>
          <idno type="ROR">https://ror.org/00cxy0s05</idno>
          <orgName>CHU Rouen</orgName>
          <desc>
            <address>
              <addrLine>1 rue de Germont 76031 Rouen cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-42992" status="VALID">
          <orgName>Département de neurologie [Lille]</orgName>
          <desc>
            <address>
              <addrLine>CHRU</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1003143" status="VALID">
          <orgName>GenoSplice [Paris]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.genosplice.com/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-542030" status="VALID">
          <orgName>Equipe Fonctions et dysfonctions de systèmes frontaux [ICM Paris]</orgName>
          <orgName type="acronym">FRONTlab</orgName>
          <desc>
            <address>
              <addrLine>Institut du Cerveau, Hôpital Pitié-Salpêtrière, 47 bd de l’Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://icm-institute.org/fr/team/equipe-dubois-levy/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-542029" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation name="U1127" active="#struct-303623" type="indirect"/>
            <relation active="#struct-353778" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
            <relation name="UM75" active="#struct-413221" type="indirect"/>
            <relation name="UMR7225" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-491479" status="VALID">
          <idno type="RNSR">201221035S</idno>
          <idno type="ROR">https://ror.org/043ja9593</idno>
          <orgName>Dynamics, Logics and Inference for biological Systems and Sequences</orgName>
          <orgName type="acronym">Dyliss</orgName>
          <date type="start">2013-07-01</date>
          <date type="end">2026-03-31</date>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu 35042 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inria.fr/equipes/dyliss</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419153" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation active="#struct-491231" type="direct"/>
            <relation active="#struct-490899" type="indirect"/>
            <relation active="#struct-105160" type="indirect"/>
            <relation active="#struct-117606" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-172265" type="indirect"/>
            <relation active="#struct-247362" type="indirect"/>
            <relation active="#struct-411575" type="indirect"/>
            <relation name="UMR6074" active="#struct-441569" type="indirect"/>
            <relation active="#struct-481355" type="indirect"/>
            <relation active="#struct-302102" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-1175218" status="VALID">
          <idno type="ROR">https://ror.org/03cjm2544</idno>
          <orgName>Centre Inria de Sorbonne Université</orgName>
          <date type="start">2022-11-01</date>
          <desc>
            <address>
              <addrLine>48 Rue Barrault, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-454310" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-454310" status="VALID">
          <idno type="IdRef">241614864</idno>
          <idno type="RNSR">196718247G</idno>
          <idno type="ROR">https://ror.org/05eyd5d35</idno>
          <orgName>Centre Inria de Paris</orgName>
          <date type="start">2016-03-10</date>
          <desc>
            <address>
              <addrLine>48 Rue Barrault, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/paris</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300906" status="VALID">
          <idno type="ROR">https://ror.org/01tc2d264</idno>
          <orgName>CHU Limoges</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-419153" status="VALID">
          <idno type="RNSR">198018249C</idno>
          <idno type="ROR">https://ror.org/04040yw90</idno>
          <orgName>Centre Inria de l'Université de Rennes</orgName>
          <desc>
            <address>
              <addrLine>Campus de beaulieu35042 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/rennes</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-491231" status="VALID">
          <orgName>GESTION DES DONNÉES ET DE LA CONNAISSANCE</orgName>
          <orgName type="acronym">IRISA-D7</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.irisa.fr/fr/departements/d7-gestion-donnees-connaissance</ref>
          </desc>
          <listRelation>
            <relation active="#struct-490899" type="direct"/>
            <relation active="#struct-105160" type="indirect"/>
            <relation active="#struct-117606" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-172265" type="indirect"/>
            <relation active="#struct-247362" type="indirect"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation active="#struct-411575" type="indirect"/>
            <relation name="UMR6074" active="#struct-441569" type="indirect"/>
            <relation active="#struct-481355" type="indirect"/>
            <relation active="#struct-302102" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-490899" status="VALID">
          <idno type="IdRef">026386909</idno>
          <idno type="ISNI">0000 0001 2298 7270</idno>
          <idno type="RNSR">200012163A</idno>
          <idno type="ROR">https://ror.org/00myn0z94</idno>
          <orgName>Institut de Recherche en Informatique et Systèmes Aléatoires</orgName>
          <orgName type="acronym">IRISA</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>Avenue du général LeclercCampus de Beaulieu 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.irisa.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-117606" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-172265" type="direct"/>
            <relation active="#struct-247362" type="direct"/>
            <relation active="#struct-300009" type="direct"/>
            <relation active="#struct-411575" type="direct"/>
            <relation name="UMR6074" active="#struct-441569" type="direct"/>
            <relation active="#struct-481355" type="direct"/>
            <relation active="#struct-302102" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-117606" status="VALID">
          <idno type="ROR">https://ror.org/04xaa4j22</idno>
          <orgName>Institut National des Sciences Appliquées - Rennes</orgName>
          <orgName type="acronym">INSA Rennes</orgName>
          <desc>
            <address>
              <addrLine>20, avenue des Buttes de Coësmes - CS 70839 - 35708 Rennes cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-172265" status="VALID">
          <idno type="IdRef">05017746X</idno>
          <idno type="ISNI">0000000121680285</idno>
          <idno type="ROR">https://ror.org/04ed7fw48</idno>
          <orgName>Université de Bretagne Sud</orgName>
          <orgName type="acronym">UBS</orgName>
          <date type="start">1995-02-07</date>
          <desc>
            <address>
              <addrLine>BP 92116 - 56321 Lorient cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-ubs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-247362" status="VALID">
          <idno type="ROR">https://ror.org/03rxtdc22</idno>
          <orgName>École normale supérieure - Rennes</orgName>
          <orgName type="acronym">ENS Rennes</orgName>
          <desc>
            <address>
              <addrLine>Campus de Ker Lann - avenue Robert Schuman - 35170 Bruz</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ens-rennes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-411575" status="VALID">
          <idno type="IdRef">184443237</idno>
          <idno type="ROR">https://ror.org/019tcpt25</idno>
          <orgName>CentraleSupélec</orgName>
          <desc>
            <address>
              <addrLine>3, rue Joliot Curie,Plateau de Moulon,91192 GIF-SUR-YVETTE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centralesupelec.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-481355" status="VALID">
          <idno type="IdRef">202743233</idno>
          <idno type="ROR">https://ror.org/030hj3061</idno>
          <orgName>IMT Atlantique</orgName>
          <orgName type="acronym">IMT Atlantique</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Brest : Technopôle Brest-Iroise CS 8381829238 BREST Cedex 3 -Campus Nantes : 4, rue Alfred Kastler- La chantrerie 44300 NANTES -Campus Rennes :  2 Rue de la Châtaigneraie, 35510 CESSON SEVIGNE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt-atlantique.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302102" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302102" status="VALID">
          <idno type="IdRef">192427156</idno>
          <idno type="ISNI">000000012202567X</idno>
          <idno type="ROR">https://ror.org/025vp2923</idno>
          <idno type="Wikidata">Q27962533</idno>
          <orgName>Institut Mines-Télécom [Paris]</orgName>
          <orgName type="acronym">IMT</orgName>
          <date type="start">2012-03-01</date>
          <desc>
            <address>
              <addrLine>19 Place Marguerite Perey, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50388" status="VALID">
          <idno type="anr">ANR-19-P3IA-0001</idno>
          <orgName>PRAIRIE</orgName>
          <desc>PaRis Artificial Intelligence Research InstitutE</desc>
          <date type="start">2019</date>
        </org>
        <org type="anrProject" xml:id="projanr-26971" status="VALID">
          <idno type="anr">ANR-10-IAHU-0006</idno>
          <orgName>IHU-A-ICM</orgName>
          <desc>Institut de Neurosciences Translationnelles de Paris</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-41011" status="VALID">
          <idno type="anr">ANR-14-CE15-0016</idno>
          <idno type="program">Appel à projets générique</idno>
          <orgName>PREV-DEMALS</orgName>
          <desc>Prédire pour prévenir les démences frontotemporales (DFT) et la sclérose latérale amyotrophique (SLA)</desc>
          <date type="start">2014</date>
        </org>
        <org type="anrProject" xml:id="projanr-38027" status="VALID">
          <idno type="anr">ANR-11-INBS-0013</idno>
          <idno type="program">Infrastructures</idno>
          <orgName>IFB (ex Renabi-IFB)</orgName>
          <desc>Institut français de bioinformatique</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>