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Integrative models for TGF-$\beta$ signaling and extracellular matrix


The extracellular matrix (ECM) is the most important regulator of cell-cell communication within tissues. ECM is a complex structure, made up of a wide variety of molecules including proteins, proteglycans and glycoaminoglycans. It contributes to cell signaling through the action of both its constituents and their proteolytic cleaved fragments called ma-tricryptins [Hynes and Naba, 2012, Ricard-Blum and Vallet, 2019]. In addition , ECM acts as a "reservoir" of growth factors and cytokines and regulates their bioavailability at the cell surface. By controlling cell signaling inputs, ECM plays a key role in regulating cell phenotype (differentiation, proliferation, migration, etc.). In this context, signaling networks associated with the polypeptide transforming growth factor TGF-β are unique since their activation are controlled by ECM and TGF-$β$ is a major regulator of ECM remodeling in return .
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hal-02458073 , version 1 (28-01-2020)



Nathalie Theret, Jérôme Feret, Arran Hodgkinson, Pierre Boutillier, Pierre Vignet, et al.. Integrative models for TGF-$\beta$ signaling and extracellular matrix. Sylvie Ricard-Blum. Extracellular Matrix Omics, 7, Springer, pp.17, 2020, Biology of Extracellular Matrix, 978-3-030-58329-3. ⟨10.1007/978-3-030-58330-9_10⟩. ⟨hal-02458073⟩
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