<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02425761</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T04:45:16+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Biochemical Threshold Function Implementation with Zero-Order Ultrasensitivity</title>
            <author role="aut">
              <persName>
                <forename type="first">Wei-Chih</forename>
                <surname>Huang</surname>
              </persName>
              <idno type="halauthorid">1427749-0</idno>
              <affiliation ref="#struct-238233"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jie-Hong</forename>
                <surname>Jiang</surname>
              </persName>
              <idno type="halauthorid">783408-0</idno>
              <affiliation ref="#struct-238233"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Fages</surname>
              </persName>
              <email type="md5">006dcbfef3f44ae16c9cade64dadab75</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">francois-fages</idno>
              <idno type="idhal" notation="numeric">11625</idno>
              <idno type="halauthorid" notation="string">12005-11625</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5650-8266</idno>
              <idno type="IDREF">https://www.idref.fr/03429502X</idno>
              <affiliation ref="#struct-454733"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Franck</forename>
                <surname>Molina</surname>
              </persName>
              <email type="md5">fe9d58cb527322ca01440d2ac8362810</email>
              <email type="domain">cpbs.univ-montp1.fr</email>
              <idno type="idhal" notation="numeric">757999</idno>
              <idno type="halauthorid" notation="string">206557-757999</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4181-0854</idno>
              <affiliation ref="#struct-562740"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>François</forename>
                <surname>Fages</surname>
              </persName>
              <email type="md5">006dcbfef3f44ae16c9cade64dadab75</email>
              <email type="domain">inria.fr</email>
            </editor>
            <funder ref="#projanr-44764"/>
            <funder>This work was supported by the BIOPSY project under grant106-2923-E-002-002-MY3 of the Ministry of Science and Tech-nology  (MOST)  of  Taiwan  and  the  National  Research  Agency (ANR) of France.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-12-31 11:14:39</date>
              <date type="whenModified">2026-02-07 05:17:59</date>
              <date type="whenReleased">2020-01-06 12:06:11</date>
              <date type="whenProduced">2019-10-17</date>
              <date type="whenEndEmbargoed">2019-12-31</date>
              <ref type="file" target="https://inria.hal.science/hal-02425761v1/document">
                <date notBefore="2019-12-31"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inria.hal.science/hal-02425761v1/file/HJFM19biocas.pdf" id="file-2425761-2315875">
                <date notBefore="2019-12-31"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="127318">
                <persName>
                  <forename>François</forename>
                  <surname>Fages</surname>
                </persName>
                <email type="md5">006dcbfef3f44ae16c9cade64dadab75</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02425761</idno>
            <idno type="halUri">https://inria.hal.science/hal-02425761</idno>
            <idno type="halBibtex">huang:hal-02425761</idno>
            <idno type="halRefHtml">&lt;i&gt;BioCAS 2019 - IEEE Biomedical Circuits and Systems Conference&lt;/i&gt;, Oct 2019, Nara, Japan. pp.1-4, &lt;a target="_blank" href="https://dx.doi.org/10.1109/BIOCAS.2019.8919176"&gt;&amp;#x27E8;10.1109/BIOCAS.2019.8919176&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">BioCAS 2019 - IEEE Biomedical Circuits and Systems Conference, Oct 2019, Nara, Japan. pp.1-4, &amp;#x27E8;10.1109/BIOCAS.2019.8919176&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2425761-2315875"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA-SACLAY" corresp="INRIA">INRIA Saclay - Ile de France</idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="TESTALAIN1">TESTALAIN1</idno>
            <idno type="stamp" n="INRIA2">INRIA 2</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="INRIA-SACLAY-2015" corresp="UNIV-PARIS-SACLAY">INRIA-SACLAY-2015</idno>
            <idno type="stamp" n="SYS2DIAG">Modélisation et ingénierie des systèmes complexes biologiques pour le diagnostic</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-COMPUTER-SCIENCE">Graduate School Computer Science</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Biochemical Threshold Function Implementation with Zero-Order Ultrasensitivity</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Wei-Chih</forename>
                    <surname>Huang</surname>
                  </persName>
                  <idno type="halauthorid">1427749-0</idno>
                  <affiliation ref="#struct-238233"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jie-Hong</forename>
                    <surname>Jiang</surname>
                  </persName>
                  <idno type="halauthorid">783408-0</idno>
                  <affiliation ref="#struct-238233"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Fages</surname>
                  </persName>
                  <email type="md5">006dcbfef3f44ae16c9cade64dadab75</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">francois-fages</idno>
                  <idno type="idhal" notation="numeric">11625</idno>
                  <idno type="halauthorid" notation="string">12005-11625</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5650-8266</idno>
                  <idno type="IDREF">https://www.idref.fr/03429502X</idno>
                  <affiliation ref="#struct-454733"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Franck</forename>
                    <surname>Molina</surname>
                  </persName>
                  <email type="md5">fe9d58cb527322ca01440d2ac8362810</email>
                  <email type="domain">cpbs.univ-montp1.fr</email>
                  <idno type="idhal" notation="numeric">757999</idno>
                  <idno type="halauthorid" notation="string">206557-757999</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4181-0854</idno>
                  <affiliation ref="#struct-562740"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>BioCAS 2019 - IEEE Biomedical Circuits and Systems Conference</title>
                  <date type="start">2019-10-17</date>
                  <date type="end">2019-10-19</date>
                  <settlement>Nara</settlement>
                  <country key="JP">Japan</country>
                </meeting>
                <imprint>
                  <publisher>IEEE</publisher>
                  <biblScope unit="pp">1-4</biblScope>
                </imprint>
              </monogr>
              <idno type="doi">10.1109/BIOCAS.2019.8919176</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="info.info-bi">Computer Science [cs]/Bioinformatics [q-bio.QM]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Engineering biochemical reactions is a key task in synthetic biology to enable biomedical and other applications. The biochemical threshold function is a crucial component in the biosensor circuits to be deployed in living cells or synthetic vesicles for disease diagnosis. In this work, based on the zero-order ultrasensitivity, we propose an economic biochemical implementation of threshold functions with reconfigurable threshold values. We show that the so-constructed threshold function module well approximates the unit step function and allows robust composition with other function modules for complex computation tasks.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-238233" status="VALID">
          <orgName>Graduate Institute of Electronics Engineering [National Taiwan University]</orgName>
          <orgName type="acronym">NTU | GIEE</orgName>
          <desc>
            <address>
              <addrLine>National Taiwan University | Room 401, Barry Lam Hall, No. 1, Sec. 4, Roosevelt Rd., Taipei 106319</addrLine>
              <country key="TW"/>
            </address>
            <ref type="url">https://giee.ntu.edu.tw/en/home/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110803" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-454733" status="VALID">
          <idno type="RNSR">201421205T</idno>
          <idno type="ROR">https://ror.org/039v8sa14</idno>
          <orgName>Computational systems biology and optimization</orgName>
          <orgName type="acronym">Lifeware</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2027-03-31</date>
          <desc>
            <address>
              <addrLine>1 rue Honoré d'Estienne d'Orves Campus de l'École Polytechnique 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/equipes/lifeware</ref>
          </desc>
          <listRelation>
            <relation active="#struct-118511" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-562740" status="VALID">
          <idno type="RNSR">200919301V</idno>
          <idno type="ROR">056mmjd70</idno>
          <orgName>Sys2Diag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic</orgName>
          <orgName type="acronym">Sys2Diag</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>CAP DELTA - 1682 RUE DE LA VALSIERE34184 MONTPELLIER CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.sys2diag.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR9005" active="#struct-441569" type="direct"/>
            <relation active="#struct-562738" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-110803" status="VALID">
          <idno type="ROR">https://ror.org/05bqach95</idno>
          <orgName>National Taiwan University</orgName>
          <orgName type="acronym">NTU</orgName>
          <desc>
            <address>
              <addrLine>No. 1, Sec. 4, Roosevelt Road, Taipei, 10617 Taiwan</addrLine>
              <country key="TW"/>
            </address>
            <ref type="url">https://www.ntu.edu.tw/english</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-118511" status="VALID">
          <idno type="RNSR">200818248E</idno>
          <idno type="ROR">https://ror.org/0315e5x55</idno>
          <orgName>Centre Inria de Saclay</orgName>
          <desc>
            <address>
              <addrLine>1 rue Honoré d'Estienne d'OrvesBâtiment Alan TuringCampus de l'École Polytechnique91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/saclay</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-562738" status="VALID">
          <orgName>Alcediag</orgName>
          <desc>
            <address>
              <addrLine>Parc EuromedecineCAP DELTA - 1682 RUE DE LA VALSIERE 34184 MONTPELLIER CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.alcediag-alcen.com/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-44764" status="VALID">
          <idno type="anr">ANR-16-CE18-0029</idno>
          <orgName>BIOPSY</orgName>
          <desc>Système de programmation à base de réseaux biochimiques</desc>
          <date type="start">2016</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>