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Pré-Publication, Document De Travail Année : 2019

Frequency gradients in heterogeneous oscillatory media can spatially localize self-organized wave sources that coordinate system-wide activity

Résumé

Rhythmogenesis, which is critical for many biological functions, involves a transition to coherent activity through cell-cell communication. In the absence of centralized coordination by specialized cells (pacemakers), competing oscillating clusters impede this global synchrony. We show that spatial symmetry-breaking through a frequency gradient results in the emergence of localized wave sources driving system-wide activity. Such gradients, arising through heterogeneous inter-cellular coupling, may explain directed rhythmic activity during labor in the uterus despite the absence of pacemakers.

Dates et versions

hal-02415287 , version 1 (17-12-2019)

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Ria Ghosh, Pavithraa Seenivasan, Shakti N. Menon, S. Sridhar, Nicolas B. Garnier, et al.. Frequency gradients in heterogeneous oscillatory media can spatially localize self-organized wave sources that coordinate system-wide activity. 2019. ⟨hal-02415287⟩
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