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Towards an automatic conversion from SBML core to SBML qual


The SBML format is the de facto standard to encode biological model in different formalisms. It was first developed to encode quantitative models like Differentials Equations (DEs), but the current release allows the definition of packages extending the core format. One of these packages, named qual, encodes qualitative models like Boolean Networks (BNs). To the best of our knowledge, there is no automatic pipeline to convert a quantitative model encoded in SBML core into a qualitative model encoded with the qual package. Here, we explore such a pipeline on a relatively simple system: the cell division of fission yeast, which has been studied both with a set DEs and with a BN. Our approach consists in extracting the model topology from the set of DEs and in solving them numerically in order to retrieve the time course data of species' concentrations on which we apply a discretization. Then we extract from these data a scarce state transition table. We are currently investigating ways to synthesize a BN fitting both topology knowledge and state transitions.
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hal-02407443 , version 1 (12-12-2019)


  • HAL Id : hal-02407443 , version 1


Athénaïs Vaginay, Malika Smail-Tabbone, Taha Boukhobza. Towards an automatic conversion from SBML core to SBML qual. Journées Ouvertes Biologie, Informatique et Mathématiques, JOBIM 2019, Jul 2019, Nantes, France. ⟨hal-02407443⟩
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