Conference Papers Year : 2019

Period -control in a coupled system of two genetic oscillators for synthetic biology

Période - contrôle dans un système couplé de deux oscillateurs génétiques pour la biologie synthétique

Abstract

Biological complex mechanisms with oscillatory behavior are often modeled by high dimensional nonlinear ODEs systems, which makes the analysis and understanding the dynamics of the system difficult. In this work, we consider two reduced models that mimic the oscillatory dynamics of the cell cycle and the circadian clock, and study their coupling from a synthetic biology perspective. To improve the performance and robustness of the oscillatory dynamics in a living cellular environment, we consider the problem of augmenting the parameter region admitting periodic solutions. Moreover, we study the capacity for mutual period regulation and control of the coupling between the two reduced oscillators.
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Dates and versions

hal-02386364 , version 1 (29-11-2019)

Identifiers

Cite

Eleni Firippi, Madalena Chaves. Period -control in a coupled system of two genetic oscillators for synthetic biology. FOSBE 2019 - 8th IFAC Conference on Foundations of Systems Biology in Engineering, Oct 2019, Valencia, Spain. ⟨10.1016/j.ifacol.2019.12.238⟩. ⟨hal-02386364⟩
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