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Article Dans Une Revue Neurobiology of Aging Année : 2012

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease

Résumé

Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is characterized by the invariant cerebral accumulation of ␤-amyloid peptide. This event occurs early in the disease process. In humans, [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) is largely used to follow-up in vivo cerebral glucose utilization (CGU) and brain metabolism modifications associated with the Alzheimer's disease pathology. Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP SweLon /PS1 M146L , a mouse model of amyloidosis. We showed an age-dependent increase of glucose uptake in several brain regions of APP/PS1 mice but not in control animals and a higher [18F]-FDG uptake in the cortex and the hippocampus of 12-month-old APP/PS1 mice as compared with age-matched control mice. We then developed a method of 3-D microscopic autoradiography to evaluate glucose uptake at the level of amyloid plaques and showed an increased glucose uptake close to the plaques rather than in amyloid-free cerebral tissues. These data suggest a macroscopic and microscopic reorganization of glucose uptake in relation to cerebral amyloidosis.
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Dates et versions

hal-02155726 , version 1 (25-05-2021)

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Géraldine Poisnel, Anne-Sophie Herard, Nadine El Tannir El Tayara, Emmanuel Bourrin, Andreas Volk, et al.. Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease. Neurobiology of Aging, 2012, 33 (9), pp.1995-2005. ⟨10.1016/j.neurobiolaging.2011.09.026⟩. ⟨hal-02155726⟩
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