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              <p>Bacteria have evolved complex regulatory networks to control the activity oftranscription and translation, and thus the growth rate, over a range of environmentalconditions. Reengineering RNA polymerase and ribosomes allows modifying naturally evolvedregulatory networks and thereby profoundly reorganizing the manner in whichbacteria allocate resources to different cellular functions. This opens new opportunitiesfor our fundamental understanding of microbial physiology and for a variety ofapplications. Recent breakthroughs in genome engineering and the miniaturization andautomation of culturing methods have offered new perspectives for the reengineeringof the transcription and translation machinery in bacteria as well as the development ofnovel in vitro and in vivo gene expression systems. We review different examples fromthe unifying perspective of resource reallocation, and discuss the impact of theseapproaches for microbial systems biology and biotechnological applications.</p>
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