%0 Conference Proceedings %T Model-free immune therapy: A control approach to acute inflammation %+ Department of Electrical Engineering and Computer Science [Knoxville] %+ Laboratoire d'informatique de l'École polytechnique [Palaiseau] (LIX) %+ ALgèbre pour Identification & Estimation Numériques (AL.I.E.N.) %+ Non-Asymptotic estimation for online systems (NON-A) %+ Centre de Recherche en Automatique de Nancy (CRAN) %+ Department of Mathematics University of Tennessee Knoxville %A Bara, Ouassim %A Fliess, Michel %A Join, Cédric %A Day, Judy %A Djouadi, Seddik, M. %< avec comité de lecture %Z CID %B 15th European Control Conference, ECC'16 %C Aalborg, Denmark %8 2016-06-29 %D 2016 %Z 1607.07259 %K model-free control %K intelligent proportional controller %K immune system %K inflammatory response %Z Life Sciences [q-bio]/Immunology %Z Life Sciences [q-bio]/Bioengineering %Z Computer Science [cs]/Biotechnology %Z Computer Science [cs]/Systems and Control [cs.SY] %Z Computer Science [cs]/Automatic Control Engineering %Z Computer Science [cs]/Artificial Intelligence [cs.AI] %Z Engineering Sciences [physics]/Automatic %Z Mathematics [math]/Optimization and Control [math.OC]Conference papers %X Control of an inflammatory immune response is still an ongoing research. Here, a strategy consisting of manipulating a pro and anti-inflammatory mediator is considered. Already existing and promising model-based techniques suffer unfortunately from a most difficult calibration. This is due to the different types of inflammations and to the strong parameter variation between patients. This communication explores another route via the new model-free control and its corresponding "intelligent" controllers. A "virtual" patient, i.e., a mathematical model, is only employed for digital simulations. A most interesting feature of our control strategy is the fact that the two outputs which must be driven are sensorless. This difficulty is overcome by assigning suitable reference trajectories to two other outputs with sensors. Several most encouraging computer simulations, corresponding to different drug treatment strategies, are displayed and discussed.. %G English %2 https://hal-polytechnique.archives-ouvertes.fr/hal-01341060/document %2 https://hal-polytechnique.archives-ouvertes.fr/hal-01341060/file/InflamECC16.pdf %L hal-01341060 %U https://hal-polytechnique.archives-ouvertes.fr/hal-01341060 %~ X %~ CNRS %~ INRIA %~ CRAN-CID %~ CRAN %~ LIX %~ INRIA-LILLE %~ INSMI %~ X-LIX %~ X-DEP %~ X-DEP-INFO %~ INRIA_TEST %~ TESTALAIN1 %~ CRISTAL %~ UNIV-LORRAINE %~ INRIA2 %~ TDS-MACS %~ UNIV-PARIS-SACLAY %~ X-SACLAY %~ UNIV-LILLE %~ INRIA-ETATSUNIS