Guidelines for reporting methodological challenges and evaluating potential bias in dementia research - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2015

Guidelines for reporting methodological challenges and evaluating potential bias in dementia research

Résumé

Clinical and population research on dementia and related neurologic conditions, including Alzheimer’s disease, faces several unique methodological challenges. Progress to identify preventive and therapeutic strategies rests on valid and rigorous analytic approaches, but the research literature reflects little consensus on “best practices.” We present findings from a large scientific working group on research methods for clinical and population studies of dementia, which identified five categories of methodological challenges as follows: (1) attrition/sample selection, including selective survival; (2) measurement, including uncertainty in diagnostic criteria, measurement error in neuropsychological assessments, and practice or retest effects; (3) specification of longitudinal models when participants are followed for months, years, or even decades; (4) time-varyingmeasurements; and (5) high-dimensional data.We explainwhy each challenge is important indementia research and howit could compromise the translation of research findings into effective prevention or care strategies. We advance a checklist of potential sources of bias that should be routinely addressed when reporting dementia research.

Dates et versions

hal-01288885 , version 1 (15-03-2016)

Identifiants

Citer

Jennifer Weuve, Cécile Proust-Lima, Melinda C. Power, Alden L. Gross, Scott M. Hofer, et al.. Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 11 (9), pp.1098-1109. ⟨10.1016/j.jalz.2015.06.1885⟩. ⟨hal-01288885⟩

Collections

INRIA INRIA2 U1219
82 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More