<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01261115</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-10T02:49:29+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A framework for creating population specific multimodal brain atlas using clinical T1 and diffusion tensor images</title>
            <author role="aut">
              <persName>
                <forename type="first">Vikash</forename>
                <surname>Gupta</surname>
              </persName>
              <idno type="idhal" notation="numeric">768322</idno>
              <idno type="halauthorid" notation="string">704499-768322</idno>
              <idno type="IDREF">https://www.idref.fr/18581686X</idno>
              <affiliation ref="#struct-30281"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Grégoire</forename>
                <surname>Malandain</surname>
              </persName>
              <email type="md5">98d96049e3d51120d76de706883d13ff</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">gregoire-malandain</idno>
              <idno type="idhal" notation="numeric">4885</idno>
              <idno type="halauthorid" notation="string">25428-4885</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-8115-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4559-1575</idno>
              <idno type="IDREF">https://www.idref.fr/077109856</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-8115-2015</idno>
              <orgName ref="#struct-300009"/>
              <affiliation ref="#struct-179332"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicholas</forename>
                <surname>Ayache</surname>
              </persName>
              <email type="md5">9acf4d3624bc46705cec66854ce9e456</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">nicholas-ayache</idno>
              <idno type="idhal" notation="numeric">833436</idno>
              <idno type="halauthorid" notation="string">142607-833436</idno>
              <idno type="ORCID">https://orcid.org/0009-0007-2359-9596</idno>
              <affiliation ref="#struct-30281"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Pennec</surname>
              </persName>
              <email type="md5">e3817180f5d1e6746b6778503187963f</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">xavier-pennec</idno>
              <idno type="idhal" notation="numeric">9074</idno>
              <idno type="halauthorid" notation="string">4843-9074</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/L-2537-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6617-7664</idno>
              <idno type="IDREF">https://www.idref.fr/035316489</idno>
              <affiliation ref="#struct-30281"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Project-Team</forename>
                <surname>Asclepios</surname>
              </persName>
              <email type="md5">153d489f712c736f0e518aaa23216ea6</email>
              <email type="domain">inria.fr</email>
            </editor>
            <funder ref="#projeurop-110280"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2016-01-23 19:23:39</date>
              <date type="whenModified">2026-04-29 13:10:10</date>
              <date type="whenReleased">2016-01-25 14:11:00</date>
              <date type="whenProduced">2015-10-09</date>
              <date type="whenEndEmbargoed">2016-01-23</date>
              <ref type="file" target="https://inria.hal.science/hal-01261115v1/document">
                <date notBefore="2016-01-23"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inria.hal.science/hal-01261115v1/file/Gupta_CDMRI_2015.pdf" id="file-1261115-1340644">
                <date notBefore="2016-01-23"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="167080">
                <persName>
                  <forename>Project-Team</forename>
                  <surname>Asclepios</surname>
                </persName>
                <email type="md5">153d489f712c736f0e518aaa23216ea6</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01261115</idno>
            <idno type="halUri">https://inria.hal.science/hal-01261115</idno>
            <idno type="halBibtex">gupta:hal-01261115</idno>
            <idno type="halRefHtml">&lt;i&gt;MICCAI 2015 Workshop on Computational Diffusion MRI (CDMRI'15)&lt;/i&gt;, Oct 2015, Munich, Germany. pp.99-108, &lt;a target="_blank" href="https://dx.doi.org/10.1007/978-3-319-28588-7_9"&gt;&amp;#x27E8;10.1007/978-3-319-28588-7_9&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">MICCAI 2015 Workshop on Computational Diffusion MRI (CDMRI'15), Oct 2015, Munich, Germany. pp.99-108, &amp;#x27E8;10.1007/978-3-319-28588-7_9&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1261115-1340644"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA-SOPHIA">INRIA Sophia Antipolis - Méditerranée</idno>
            <idno type="stamp" n="I3S">Laboratoire d'Informatique, Signaux et Systèmes de Sophia-Antipolis</idno>
            <idno type="stamp" n="INRIASO">INRIA-SOPHIA</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="ASCLEPIOS">ASCLEPIOS</idno>
            <idno type="stamp" n="TESTALAIN1">TESTALAIN1</idno>
            <idno type="stamp" n="INRIA2">INRIA 2</idno>
            <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno>
            <idno type="stamp" n="INRIA-300009">Inria 300009</idno>
            <idno type="stamp" n="IBV">Collection de l'Institut de Biologie Valrose </idno>
            <idno type="stamp" n="TEST-NICE">test nice</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A framework for creating population specific multimodal brain atlas using clinical T1 and diffusion tensor images</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Vikash</forename>
                    <surname>Gupta</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">768322</idno>
                  <idno type="halauthorid" notation="string">704499-768322</idno>
                  <idno type="IDREF">https://www.idref.fr/18581686X</idno>
                  <affiliation ref="#struct-30281"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Grégoire</forename>
                    <surname>Malandain</surname>
                  </persName>
                  <email type="md5">98d96049e3d51120d76de706883d13ff</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">gregoire-malandain</idno>
                  <idno type="idhal" notation="numeric">4885</idno>
                  <idno type="halauthorid" notation="string">25428-4885</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-8115-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4559-1575</idno>
                  <idno type="IDREF">https://www.idref.fr/077109856</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-8115-2015</idno>
                  <orgName ref="#struct-300009"/>
                  <affiliation ref="#struct-179332"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicholas</forename>
                    <surname>Ayache</surname>
                  </persName>
                  <email type="md5">9acf4d3624bc46705cec66854ce9e456</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">nicholas-ayache</idno>
                  <idno type="idhal" notation="numeric">833436</idno>
                  <idno type="halauthorid" notation="string">142607-833436</idno>
                  <idno type="ORCID">https://orcid.org/0009-0007-2359-9596</idno>
                  <affiliation ref="#struct-30281"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Pennec</surname>
                  </persName>
                  <email type="md5">e3817180f5d1e6746b6778503187963f</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">xavier-pennec</idno>
                  <idno type="idhal" notation="numeric">9074</idno>
                  <idno type="halauthorid" notation="string">4843-9074</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/L-2537-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6617-7664</idno>
                  <idno type="IDREF">https://www.idref.fr/035316489</idno>
                  <affiliation ref="#struct-30281"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>MICCAI 2015 Workshop on Computational Diffusion MRI (CDMRI'15)</title>
                  <date type="start">2015-10-09</date>
                  <date type="end">2015-10-09</date>
                  <settlement>Munich</settlement>
                  <country key="DE">Germany</country>
                </meeting>
                <imprint>
                  <biblScope unit="serie">Computational Diffusion MRI</biblScope>
                  <biblScope unit="pp">99-108</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/978-3-319-28588-7_9</idno>
              <ref type="publisher">http://cmic.cs.ucl.ac.uk/cdmri15/</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">DTI-T1 brain template</term>
                <term xml:lang="en">HIV</term>
                <term xml:lang="en">Probabilistic white matter parcel-lation map</term>
                <term xml:lang="en">Multimodal brain atlas</term>
              </keywords>
              <classCode scheme="halDomain" n="info.info-im">Computer Science [cs]/Medical Imaging</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Spatial normalization is one of the most important steps in population based statistical analysis of brain images. This involves normalizing all the brain images to a pre-defined template or a population specific template. With multiple emerging imaging modalities, it is quintessential to develop a method for building a joint template that is a statistical representation of the given population across different modalities. It is possible to create different population specific templates in different modalities using existing methods. However, they do not give an opportunity for voxelwise comparison of different modalities. A multimodal brain template with probabilistic region of interest (ROI) definitions will give opportunity for multivariate statistical frameworks for better understanding of brain diseases. In this paper, we propose a methodology for developing such a multimodal brain atlas using the anatomical T1 images and the diffusion tensor images (DTI), along with an automated workflow to probabilistically define the different white matter regions on the population specific multimodal template. The method will be useful to carry out ROI based statistics across different modalities even in the absence of expert segmentation. We show the effectiveness of such a template using voxelwise multivariate statistical analysis on population based group studies on HIV/AIDS patients. 1 The need for a probabilistic multimodal atlas The growth in brain imaging data across different modalities gives an opportunity to understand the disease progression and make correlations across them. Statistical analysis across different modalities and across population require spatial normalization. All the brain images are often normalized to a pre-defined template, for example the ICBM-152 or MNI template. However in [1] and [2], the authors have shown that choosing a generic template biases the statistical presently at Imaging Genetics Center, University of Southern California presently at MORPHENE team, INRIA Sophia-Antipolis</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-30281" status="OLD">
          <idno type="RNSR">200518380L</idno>
          <orgName>Analysis and Simulation of Biomedical Images</orgName>
          <orgName type="acronym">ASCLEPIOS</orgName>
          <date type="start">2005-01-11</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>2004 route des lucioles, BP93 06902 Sophia Antipolis Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www-sop.inria.fr/asclepios</ref>
          </desc>
          <listRelation>
            <relation active="#struct-34586" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-179332" status="VALID">
          <idno type="RNSR">201120999G</idno>
          <idno type="ROR">https://ror.org/00xcapc45</idno>
          <orgName>Morphologie et Images</orgName>
          <orgName type="acronym">MORPHEME</orgName>
          <date type="start">2013-07-01</date>
          <date type="end">2026-09-30</date>
          <desc>
            <address>
              <addrLine>Laboratoire I3S - Algorithmes - Sophia Antipolisroute des lucioles06902 Sophia Antipolis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www-sop.inria.fr/morpheme/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-34586" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation name="U1091" active="#struct-182201" type="direct"/>
            <relation active="#struct-117617" type="indirect"/>
            <relation name="U1091" active="#struct-303623" type="indirect"/>
            <relation name="UMR7277" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1039632" type="indirect"/>
            <relation active="#struct-452158" type="direct"/>
            <relation active="#struct-13009" type="indirect"/>
            <relation name="UMR7271" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-34586" status="VALID">
          <idno type="RNSR">198318250R</idno>
          <idno type="ROR">https://ror.org/01nzkaw91</idno>
          <orgName>Centre Inria d'Université Côte d'Azur</orgName>
          <desc>
            <address>
              <addrLine>2004 route des Lucioles BP 93 06902 Sophia Antipolis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/sophia/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-182201" status="VALID">
          <idno type="RNSR">201220170B</idno>
          <idno type="ROR">03bnma344</idno>
          <orgName>Institut de Biologie Valrose</orgName>
          <orgName type="acronym">IBV</orgName>
          <desc>
            <address>
              <addrLine>Faculté des Sciences, parc Valrose 06108 Nice cedex 2</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="U1091" active="#struct-303623" type="direct"/>
            <relation name="UMR7277" active="#struct-441569" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-117617" status="VALID">
          <idno type="IdRef">026403498</idno>
          <idno type="ISNI">0000000123372892</idno>
          <idno type="ROR">https://ror.org/02k9vew78</idno>
          <orgName>Université Nice Sophia Antipolis (1965 - 2019)</orgName>
          <orgName type="acronym">UNS</orgName>
          <date type="start">1965-10-23</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 06100 Nice</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1039632" status="VALID">
          <idno type="IdRef">241035694</idno>
          <idno type="ROR">https://ror.org/019tgvf94</idno>
          <orgName>Université Côte d'Azur</orgName>
          <orgName type="acronym">UniCA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 28, avenue Valrose 06108 Nice Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://univ-cotedazur.fr</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-452158" status="VALID">
          <orgName>Signal, Images et Systèmes</orgName>
          <orgName type="acronym">Laboratoire I3S - SIS</orgName>
          <date type="start">2016-03-03</date>
          <desc>
            <address>
              <addrLine>Laboratoire I3SCS 4012106903 Sophia Antipolis Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.i3s.unice.fr/sis</ref>
          </desc>
          <listRelation>
            <relation active="#struct-13009" type="direct"/>
            <relation active="#struct-117617" type="indirect"/>
            <relation name="UMR7271" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1039632" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-13009" status="VALID">
          <idno type="IdRef">050320491</idno>
          <idno type="ISNI">0000000105613840</idno>
          <idno type="RNSR">201220432L</idno>
          <idno type="ROR">https://ror.org/01215r597</idno>
          <orgName>Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis</orgName>
          <orgName type="acronym">I3S</orgName>
          <desc>
            <address>
              <addrLine>2000, route des Lucioles - Les Algorithmes - bât. Euclide B 06900 Sophia Antipolis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.i3s.unice.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="UMR7271" active="#struct-441569" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="europeanProject" xml:id="projeurop-110280" status="VALID">
          <idno type="number">291080</idno>
          <idno type="program">ERC-2011-ADG_20110209</idno>
          <idno type="call">ERC-2011-ADG_20110209</idno>
          <orgName>MEDYMA</orgName>
          <desc>Biophysical Modeling and Analysis of Dynamic Medical Images</desc>
          <date type="start">2012-01-04</date>
          <date type="end">2017-03-31</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>