External globus pallidus stimulation modulates brain connectivity in Huntington's disease. - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Journal of Cerebral Blood Flow and Metabolism Year : 2011

External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Abstract

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.

Domains

Medical Imaging

Dates and versions

hal-00795751 , version 1 (28-02-2013)

Identifiers

Cite

Noémie Ligot, Pierre Krystkowiak, Clémence Simonin, Serge Goldman, Philippe Peigneux, et al.. External globus pallidus stimulation modulates brain connectivity in Huntington's disease.. Journal of Cerebral Blood Flow and Metabolism, 2011, 31 (1), pp.41-6. ⟨10.1038/jcbfm.2010.186⟩. ⟨hal-00795751⟩
212 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More