External globus pallidus stimulation modulates brain connectivity in Huntington's disease.
Noémie Ligot
,
Pierre Krystkowiak
(1)
,
Clémence Simonin
(2)
,
Serge Goldman
(3)
,
Philippe Peigneux
(4)
,
John van Naemen
,
Michel Monclus
,
Simon Frédéric Lacroix
,
David Devos
(5)
,
Kathy Dujardin
(6)
,
Christine Delmaire
(7)
,
Eric Bardinet
(8, 9)
,
Arnaud Delval
,
Marie Delliaux
,
Luc Defebvre
,
Jerome Yelnik
(10, 8)
,
Serge Blond
(11)
,
Alain Destée
(6)
,
Xavier de Tiège
1
Service de neurologie [Amiens]
2 Noyaux gris centraux
3 ULB - Hôpital Erasme [Bruxelles]
4 Neuropsychology and Functional Neuroimaging Research Unit - UR2NF
5 IMRT, EA2683 - Department of Neurology et Pathologie du Mouvement
6 Département de neurologie [Lille]
7 Services de neuroradiologie [Lille]
8 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
9 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
10 CIC AP-HP (pitie-Salpetriere)/inserm
11 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
2 Noyaux gris centraux
3 ULB - Hôpital Erasme [Bruxelles]
4 Neuropsychology and Functional Neuroimaging Research Unit - UR2NF
5 IMRT, EA2683 - Department of Neurology et Pathologie du Mouvement
6 Département de neurologie [Lille]
7 Services de neuroradiologie [Lille]
8 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
9 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
10 CIC AP-HP (pitie-Salpetriere)/inserm
11 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
Noémie Ligot
- Function : Author
Pierre Krystkowiak
- Function : Author
- PersonId : 1149993
- IdRef : 059356502
John van Naemen
- Function : Author
Michel Monclus
- Function : Author
Simon Frédéric Lacroix
- Function : Author
David Devos
- Function : Author
- PersonId : 13309
- IdHAL : david-devos
- ORCID : 0000-0002-2417-799X
- IdRef : 091996309
Arnaud Delval
- Function : Author
Marie Delliaux
- Function : Author
Luc Defebvre
- Function : Author
Xavier de Tiège
- Function : Author
Abstract
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.