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Journal Articles Journal of Neurology, Neurosurgery and Psychiatry Year : 2010

Sleep disturbance and impulsive-compulsive behaviours in Parkinson's Disease

Sean S O'Sullivan
  • Function : Author
  • PersonId : 900532
Clare M Loane
  • Function : Author
  • PersonId : 900533
Andrew D Lawrence
  • Function : Author
  • PersonId : 900534
Paola Piccini
  • Function : Author
  • PersonId : 900536
Andrew J Lees
  • Function : Correspondent author
  • PersonId : 900532

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Abstract

Objectives: Impulsive-compulsive behaviours (ICBs) in Parkinson's Disease (PD) have been anecdotally linked with disturbed sleep. We investigate measures of sleep in PD patients with and without ICBs, and in healthy controls. Methods: We compare Parkinsonian features, measures of depression, anxiety and mania, and sleep disturbance in 30 PD patients with ICBs (PD+ICB), 62 PD patients without ICBs (PD - ICB), and 48 healthy controls. Results: PD+ICB patients had younger age of PD onset, had taken more dopamine replacement therapy (DRT), had worse sleep, and elevated anxiety, depression and mania scores. Using multiple linear regression analyses, the total anxiety and depression scores, and presence of ICBs were the only variables associated with poorer sleep in PD. Conclusions: PD+ICB patients may show enhanced psychomotor responses to DRT that may in turn contribute to poor sleep quality. Sleep disturbance should be specifically enquired about in PD+ICB patients.
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hal-00591160 , version 1 (07-05-2011)

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Sean S O'Sullivan, Clare M Loane, Andrew D Lawrence, Andrew H Evans, Paola Piccini, et al.. Sleep disturbance and impulsive-compulsive behaviours in Parkinson's Disease. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 82 (6), pp.620. ⟨10.1136/jnnp.2009.186874⟩. ⟨hal-00591160⟩

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