Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Breast Cancer Research and Treatment Année : 2010

Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer

Résumé

Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer. We aimed to validate the influence of Ep-CAM RNA expression in untreated node-negative breast cancer. Ep-CAM RNA expression was evaluated utilizing microarray-based gene-expression profiling in 194 consecutive node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting. The prognostic significance of Ep-CAM RNA expression for disease-free survival (DFS), metastasis-free survival (MFS), and breast cancer-specific overall survival (OS) was evaluated in univariate and multivariate analysis adjusted for age, grading, pTstage, ER as well as PR receptor and HER-2 status. Additionally, Ep-CAM RNA expression was compared with immunohistochemistry (IHC) for Ep-CAM in 194 patients. The prognostic impact of Ep-CAM gene expression was validated in further 588 node-negative breast cancer patients. Levels of Ep-CAM RNA expression showed a significant correlation with IHC ( = 0.001) and predicted in univariate analysis DFS ( = 0.001, HR = 2.4), MFS ( = 0.003, HR = 2.5), and OS ( = 0.002, HR = 3.1) accurately. The prognostic influence of Ep-CAM RNA was significant also in multivariate analysis for DFS ( = 0.017, HR = 2.0), MFS ( = 0.049, HR = 1.9), and OS ( = 0.042, HR = 2.3), respectively. The association with MFS was confirmed in an independent validation cohort in univariate ( = 0.006, HR = 1.9) and multivariate ( = 0.035, HR = 1.7) analysis. Ep-CAM RNA correlated with the proliferation metagene ( < 0.001, R=0.425) Nevertheless, in multivariate analysis, Ep-CAM was associated with MFS independent from the proliferation metagene ( = 0.030, HR = 1.8). In conclusion, Ep-CAM RNA expression is associated with poor MFS in three cohorts of untreated node-negative breast cancer.
Fichier principal
Vignette du fichier
PEER_stage2_10.1007%2Fs10549-010-0856-5.pdf (157.84 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00561313 , version 1 (01-02-2011)

Identifiants

Citer

Marcus Schmidt, Ilka Brigitte Petry, Daniel Böhm, Antje Lebrecht, Christian Törne, et al.. Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer. Breast Cancer Research and Treatment, 2010, 125 (3), pp.637-646. ⟨10.1007/s10549-010-0856-5⟩. ⟨hal-00561313⟩

Collections

PEER
213 Consultations
263 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More