Effects of a Genome-Wide Supported Psychosis Risk Variant on Neural Activation during a Theory-of-Mind Task - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Molecular Psychiatry Année : 2010

Effects of a Genome-Wide Supported Psychosis Risk Variant on Neural Activation during a Theory-of-Mind Task

Résumé

Schizophrenia is associated with marked deficits in theory of mind (ToM), a higher order form of social cognition representing the thoughts, emotions and intentions of others. Altered brain activation in medial prefrontal and temporo-parietal cortex during ToM tasks has been found in patients with schizophrenia, but the relevance of these neuroimaging findings for the heritable risk for schizophrenia is unclear. We tested the hypothesis that activation of the ToM-Network is altered in healthy risk allele carriers of the single nucleotide polymorphism rs1344706 in the gene ZNF804A, a recently discovered risk variant for psychosis with genome-wide support. 109 healthy volunteers of both sexes in Hardy-Weinberg-equilibrium for rs1344706 were investigated with functional magnetic resonance imaging during a ToM task. As hypothesized, risk carriers exhibited a significant (p < 0.05 false discovery rate, corrected for multiple comparisons) risk allele dose effect on neural activity in the medial prefrontal cortex and left temporo-parietal cortex. Moreover, the same effect was found in the left inferior parietal cortex and left inferior frontal cortex which are part of the human analogue of the mirror neuron system. Additionally, in an exploratory analysis (p < 0.001 uncorrected), we found evidence for aberrant functional connectivity between frontal and temporo-parietal regions in risk allele carriers. To conclude, we show that a dysfunction of the ToM-network is associated with a genome wide supported genetic risk variant for schizophrenia and has promise as an intermediate phenotype that can be mined for the development of biological interventions targeted to social dysfunction in psychiatry.
Fichier principal
Vignette du fichier
PEER_stage2_10.1038%2Fmp.2010.18.pdf (215.24 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00517933 , version 1 (16-09-2010)

Identifiants

Citer

Henrik Walter, Knut Schnell, Susanne Erk, Claudia Arnold, Peter Kirsch, et al.. Effects of a Genome-Wide Supported Psychosis Risk Variant on Neural Activation during a Theory-of-Mind Task. Molecular Psychiatry, 2010, n/a (n/a), pp.n/a-n/a. ⟨10.1038/mp.2010.18⟩. ⟨hal-00517933⟩

Collections

PEER
158 Consultations
444 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More