14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Experimental Gerontology Année : 2008

14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.

Résumé

Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.
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Dates et versions

hal-00345888 , version 2 (12-12-2008)
hal-00345888 , version 1 (09-07-2010)

Identifiants

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Caroline Araiz, Marie-Thérèse Château, Simon Galas. 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.. Experimental Gerontology, 2008, 43 (6), pp.505-19. ⟨10.1016/j.exger.2008.03.001⟩. ⟨hal-00345888v2⟩
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