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Article Dans Une Revue Magnetic Resonance in Medicine Année : 2007

Transversal relaxation time measured by MRI reflects brain amyloidosis in young APP/PS1 transgenic mice

Résumé

Amyloid deposits are one of the hallmarks of Alzheimer's disease (AD), one of the most devastating neurodegenerative disorders. In transgenic mice modeling Alzheimer's pathology, the MR transverse relaxation time (T(2)) has been described to be modulated by amyloidosis. This modification has been attributed to the age-related iron deposition that occurs within the amyloid plaques of old animals. In the present study, young APP/PS1 transgenic mice without histochemically detectable iron in the brain were specifically studied. In vivo measurements of T(2) in the hippocampus, at the level of the subiculum, were shown to reflect the density of amyloid plaques. This suggests that T(2) variations can be induced solely by aggregated amyloid deposits in the absence of associated histologically-detectable iron. Thus T(2) from regions with high amyloid load, such as the subiculum, is particularly well suited for following plaque deposition in young animals, i.e., at the earliest stages of the pathological process.

Domaines

Neurobiologie
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Dates et versions

hal-00320367 , version 1 (25-05-2021)

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Nadine El Tannir El Tayara, Marc Dhenain, Andreas Volk, Benoit Delatour. Transversal relaxation time measured by MRI reflects brain amyloidosis in young APP/PS1 transgenic mice. Magnetic Resonance in Medicine, 2007, 58 (1), pp.179-184. ⟨10.1002/mrm.21266⟩. ⟨hal-00320367⟩
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