Optical readout of gold nanoparticles-based DNA microarrays without silver enhancement
Résumé
We present a novel readout scheme for gold nanoparticle-based DNA microarrays relying on Laser Induced Scattering around a NanoAbsorber (LISNA). It provides direct counting of individual nanoparticles present on each array spot and stable signals, without any silver enhancement. Given the detection of nanometer-sized particles, which minimize the steric hindrance, the linear dynamic range of the method is particularly large and well suited for microarray detection.
Domaines
Optique [physics.optics]
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