Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Cellular Microbiology Année : 2006

Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice

Résumé

In vivo imaging of small animals is a rapidly developing field. However, the potential of global imaging of infectious processes in animal models remains poorly explored. We used magnetic resonance imaging (MRI) to follow the development and regression of inflammatory lesions caused by infection by Klebsiella pneumoniae in mouse lungs. A virulent strain caused an intense inflammation within 2 days in the whole lungs, while an avirulent strain did not show significant changes. Mice infected with the virulent strain and subsequently treated with antibiotics presented a severe inflammation localized mainly in the left lung that disappeared after a week. The lesions observed by MRI correlated with the damage seen by histological analysis and a 3D representation of the tissue allowed better visualization of the development and healing of inflammatory lesions. MRI thus represents a powerful technique to study in vivo the interactions between a pathogen and its host in real time.
Fichier non déposé

Dates et versions

hal-00088937 , version 1 (07-08-2006)

Identifiants

Citer

R. Tournebize, B.T. Doan, M.A. Dillies, S. Maurin, J.C. Beloeil, et al.. Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice. Cellular Microbiology, 2006, 8, pp.33-43. ⟨10.1111/j.1462-5822.2005.00597.x⟩. ⟨hal-00088937⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More